Health Physics Society Journal

November 2015, Volume 109, Number 5

On the cover: Images taken from the Eclipse treatment-planning system, where the radiation physics core defines the whole thorax and lung fields exposed to the prescribed radiation dose. The top left image depicts the center of the radiation beam. A yellow box displays the posterior radiation beam projection encompassing the area to which the dose will be delivered. CT data are used to digitally reconstruct a radiograph. Both lungs with an expanded planning volume are represented in the top right image. Contoured outlines of the heart, lungs, and the planning volume are displayed in the bottom left and center (axial and sagittal) images. The dose volume histogram (DVH) seen in the bottom right image is a graphical method used to evaluate the percentage of volume of lung that is receiving a given dose. Heart doses are displayed on this DVH as well. From the DVH data in tabulated form, the mean lung and mean heart doses are calculated.

SPECIAL ISSUE: The Medical Countermeasures Against Radiological Threats (MCART) Consortium

CONTENTS

GUEST EDITORIAL

The MCART Consortium Animal Model Series — Thomas J. MacVittie

PAPERS

The Hematopoietic Syndrome of the Acute Radiation Syndrome in Rhesus Macaques: A Systematic Review of the Lethal Dose Response Relationship — Thomas J. MacVittie, Ann M. Farese, and William Jackson III

Mean Organ Doses Resulting From Non-Human Primate Whole Thorax Lung Irradiation Prescribed to Mid-Line Tissue — Charlotte Prado, Abdul Kazi, Alexander Bennett, Thomas MacVittie, and Karl Prado

Increased Expression of Connective Tissue Growth Factor (CTGF) in Multiple Organs After Exposure of Non-Human Primates (NHP) to Lethal Doses of Radiation — Pei Zhang, Wanchang Cui, Kim G. Hankey, Allison M. Gibbs, Cassandra P. Smith, Cheryl Taylor-Howell, Sean R. Kearney, and Thomas J. MacVittie

The H-ARS Dose Response Relationship (DRR): Validation and Variables — P. Artur Plett, Carol H. Sampson, Hui Lin Chua, William Jackson, Sasidhar Vemula, Rajendran Sellamuthu, Alexa Fisher, Hailin Feng, Tong Wu, Thomas J. MacVittie, and Christie M. Orschell

The Delayed Effects of Acute Radiation Syndrome: Evidence of Long-Term Functional Changes in the Clonogenic Cells of the Small Intestine — Catherine Booth, Gregory L. Tudor, Barry P. Katz, and Thomas J. MacVittie

Lymphoid and Myeloid Recovery in Rhesus Macaques Following Total Body X-Irradiation — Ann M. Farese, Kim G. Hankey, Melanie Veirs Cohen, and Thomas J. MacVittie

The Effect of Radiation Dose and Variation in NeupogenA Initiation Schedule on the Mitigation of Myelosuppression During the Concomitant GI-ARS and H-ARS in a Nonhuman Primate Model of High-Dose Exposure With Marrow Sparing — Thomas J. MacVittie, Alexander W. Bennett, Ann M. Farese, Cheryl Taylor-Howell, Cassandra P. Smith, Allison M. Gibbs, Karl Prado, and William Jackson III

Citrulline as a Biomarker in the Non-Human Primate Total- and Partial-Body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury — Jace W. Jones, Alexander Bennett, Claire L. Carter, Gregory Tudor, Kim G. Hankey, Ann M. Farese, Catherine Booth, Thomas J. MacVittie, and Maureen A. Kane

Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology — Jace W. Jones, Gregory Tudor, Fei Li, Yan Tong, Barry Katz, Ann M. Farese, Thomas J. MacVittie, Catherine Booth, and Maureen A. Kane

A MALDI-MSI Approach to the Characterization of Radiation-Induced Lung Injury and Medical Countermeasure Development — Claire L. Carter, Jace W. Jones, Kory Barrow, Kaitlyn Kieta, Cheryl Taylor-Howell, Sean Kearney, Cassandra P. Smith, Allison Gibbs, Ann M. Farese, Thomas J. MacVittie, and Maureen A. Kane

The Evolving MCART Multimodal Imaging Core: Establishing a Protocol for Computed Tomography and Echocardiography in the Rhesus Macaque to Perform Longitudinal Analysis of Radiation-Induced Organ Injury — Eduardo B. de Faria, Kory R. Barrow, Bradley T. Ruehle, Jordan T. Parker, Elisa Swartz, Cheryl Taylor-Howell, Kaitlyn M. Kieta, Cynthia J. Lees, Meg M. Sleeper, Travis Dobbin, Adam D. Baron, Pranshu Mohindra, and Thomas J. MacVittie

Comparing the Hematopoetic Syndrome Time Course in the NHP Animal Model to Radiation Accident Cases From the Database Search — Dieter H. Graessle, Harald Dörr, Alexander Bennett, Alla Shapiro, Ann M. Farese, Thomas J. MacVittie, and Viktor Meineke

An Interlaboratory Validation of the Radiation Dose Response Relationship (DRR) for H-ARS in the Rhesus Macaque — Karla D. Thrall, Ruschelle Love, Kyle C. O'Donnell, Ann M. Farese, Ronald Manning, and Thomas J. MacVittie

Delayed Effects of Acute Radiation Exposure in a Murine Model of the H-ARS: Multiple-Organ Injury Consequent to <10 Gy Total Body Irradiation — Joseph L. Unthank, Steven J. Miller, Ariel K. Quickery, Ethan L. Ferguson, Meijing Wang, Carol H. Sampson, Hui Lin Chua, Matthew R. DiStasi, Hailin Feng, Alexa Fisher, Barry P. Katz, P. Artur Plett, George E. Sandusky, Rajendran Sellamuthu, Sasidhar Vemula, Eric P. Cohen, Thomas J. MacVittie, and Christie M. Orschell

OTHER CONTENT

News and Notices

Health Physics Society Prospectus

Health Physics Society Affiliate Members

Author Guidelines

Advertisers Guide

Advertisers Index

Up and Coming

Health Physics (ISSN 0017-9078) is the Official Journal of the Health Physics Society and is published monthly by Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436. For news and abstracts, and to search past issues of the Health Physics Journal, please visit the Health Physics Journal website.