Health Physics Society Journal

January 2014, Volume 106, Number 1

On the cover: Matrix-assisted laser desorption ionization–mass spectrometry imaging (MALDI-MSI) of mouse lung. Unique ion markers visualized in mouse lung: (Left side, top to bottom) cyan, m/z 838; magenta, m/z 783; yellow, m/z 616. (Center) overlay of cyan, m/z 838; magenta, m/z 783; yellow, m/z 616. (Right side, top to bottom) green, m/z 707; white, m/z 761; hematoxylin and eosin (H&E). Pixel saturation is representative of relative abundance of the ion in MALDI-MSI images. See Alison J. Scott and colleagues, "Mass Spectrometry Imaging Enriches Biomarker Discovery Approaches with Candidate Mapping," p. 120, and Jones et al. Identification and Quantitation of Biomarkers for Radiation-Induced Injury via Mass Spectrometry, p. 106.

CONTENTS

GUEST EDITORIAL

The MCART Consortium Animal Models Series: An Evolving MCART — Thomas J. MacVittie

PAPERS

PEGylated G-CSF (BBT-015), GM-CSF (BBT-007), AND IL-11 (BBT-059) Analogs Enhance Survival and Hematopoietic Cell Recovery in a Mouse Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome — Paul Artur Plett, Hui Lin Chua, Carol H. Sampson, Barry P. Katz, Christine M. Fam, Lana J. Anderson, George N. Cox, and Christie M. Orschell

Survival Efficacy of the PEGylated G-CSFs Maxy-G34 and Neulasta in a Mouse Model of Lethal H-ARS, and Residual Bone Marrow Damage in Treated Survivors — Hui Lin Chua, P. Artur Plett, Carol H. Sampson, Barry P. Katz, Gilbert W. Carnathan, Thomas J. MacVittie, Keith Lenden, and Christie M. Orschell

The Ability of Filgrastim to Mitigate Mortality Following LD50/60 Total-body Irradiation Is Administration Time-Dependent — Ann M. Farese, Cassandra R. Brown, Cassandra P. Smith, Allison M. Gibbs, Barry P. Katz, Cynthia S. Johnson, Karl L. Prado, and Thomas J. MacVittie

Characterization of the Dose Response Relationship for Lung Injury Following Acute Radiation Exposure in Three Well-established Murine Strains: Developing an Interspecies Bridge to Link Animal Models with Human Lung — Isabel L. Jackson, Pu-ting Xu, Giao Nguyen, Julian D. Down, Cynthia S. Johnson, Barry P. Katz, Caroline C. Hadley, and Zeljko Vujaskovic

The Delayed Pulmonary Syndrome Following Acute High-dose Irradiation: A Rhesus Macaque Model — Michael Garofalo, Alexander Bennett, Ann M. Farese, Amanda Ward, Cheryl Taylor-Howell, Wanchang Cui, Allison Gibbs, Giovanni Lasio, William Jackson III, and Thomas J. MacVittie

A Pilot Study in Rhesus Macaques to Assess the Treatment Efficacy of a Small Molecular Weight Catalytic Metalloporphyrin Antioxidant (AEOL 10150) in Mitigating Radiation-induced Lung Damage — Michael C. Garofalo, Amanda A. Ward, Ann M. Farese, Alexander Bennett, Cheryl Taylor-Howell, Wanchang Cui, Allison Gibbs, Karl L. Prado, and Thomas J. MacVittie

Immune Cell Reconstitution After Exposure to Potentially Lethal Doses of Radiation in the Nonhuman Primate — Thomas J. MacVittie, Alexander W. Bennett, Melanie V. Cohen, Ann M. Farese, Adam Higgins, and Kim G. Hankey

The MCART Radiation Physics Core: The Quest for Radiation Dosimetry Standardization — Abdul M. Kazi, Thomas J. MacVittie, Giovanni Lasio, Wei Lu, and Karl L. Prado

Identification and Quantitation of Biomarkers for Radiation-induced Injury via Mass Spectrometry — Abdul M. Kazi, Thomas J. MacVittie, Giovanni Lasio, Wei Lu, and Karl L. Prado

Mass Spectrometry Imaging Enriches Biomarker Discovery Approaches with Candidate Mapping — Alison J. Scott, Jace W. Jones, Christie M. Orschell, Thomas J. MacVittie, Maureen A. Kane, and Robert K. Ernst

Linking the Human Response to Unplanned Radiation and Treatment to the Nonhuman Primate Response to Controlled Radiation and Treatment — Harald Dörr, Andreas Lamkowski, Dieter H. Graessle, Alexander Bennett, Alla Shapiro, Ann M. Farese, Michael Garofalo, Thomas J. MacVittie, and Viktor Meineke

PAPERS

Welcome to the NCRP Forty-Eighth Annual Meeting — Thomas S. Tenforde

WARREN K. SINCLAIR KEYNOTE ADDRESS

Ninth Annual Warren K. Sinclair Keynote Address: Effects of Childhood Radiation Exposure: An Issue From Computed Tomography Scans to Fukushima — Fred A. Mettler, Jr., Louis S. Constine, Dietmar Nosske, and Roy E. Shore

OTHER CONTENT

News and Notices

Health Physics Society Prospectus

Health Physics Society Affiliate Members

Author Guidelines

Advertisers Guide

Advertisers Index

Up and Coming

Health Physics (ISSN 0017-9078) is the Official Journal of the Health Physics Society and is published monthly by Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436. For news and abstracts, and to search past issues of the Health Physics Journal, please visit the Health Physics Journal website.