Health Physics Society Journal

October 2012, Volume 103, Number 4

On the cover: Bone Marrow: Femur-derived bone marrow of a nonhuman primate (NHP) preirradiation (left) and 19 days post-10.0 Gy total body irradiation (TBI) (right), stained with hematoxylin and eosin (H&E). 10X magnification shows significant loss of marrow cellularity. See MacVittie et al., "The Prolonged Gastrointestinal Syndrome in Rhesus Macaques: The Relationship Between Gastrointestinal, Hematopoietic, and Delayed Multi-Organ Sequelae following Acute, Potentially Lethal, Partial-Body Irradiation," p. 427.   GI: Jejunum of a mouse preirradiation (left) and 4 days post-13.0 Gy TBI (right), stained with H&E. 20X magnification shows crypt clonogen cell death and villus blunting. By day 4 several crypts are lost, but those with surviving clonogens are regenerating. See Booth et al., "Acute Gastrointestinal Syndrome in High-Dose Irradiated Mice," p. 383.   Lung: Computed tomography scans of the lungs of a NHP preirradiation (left) and 61 days post-11.5 Gy partial body irradiation (right). Significant pneumonitis is evident in the postirradiation scan. See MacVittie et al., "The Prolonged Gastrointestinal Syndrome in Rhesus Macaques: The Relationship between Gastrointestinal, Hematopoietic, and Delayed Multi-Organ Sequelae following Acute, Potentially Lethal, Partial-Body Irradiation, p. 427.

ANIMAL MODELS ISSUE: THE MEDICAL COUNTERMEASURES AGAINST RADIOLOGICAL THREATS (MCART) CONSORTIUM

CONTENTS

GUEST EDITORIAL

The MCART Consortium Animal Models Series — Thomas J. MacVittie

PAPERS

Establishing a Murine Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome — P. Artur Plett, Carol H. Sampson, Hui Lin Chua, Mandar Joshi, Catherine Booth, Alec Gough, Cynthia S. Johnson, Barry P. Katz, Ann M. Farese, Jeffrey Parker, Thomas J. MacVittie, and Christie M. Orschell

Long-Term Hematopoietic Stem Cell Damage in a Murine Model of the Hematopoietic Syndrome of the Acute Radiation Syndrome — Hui Lin Chua, P. Artur Plett, Carol H. Sampson, Mandar Joshi, Rebeka Tabbey, Barry P. Katz, Thomas J. MacVittie, and Christie M. Orschell

A Nonhuman Primate Model of the Hematopoietic Acute Radiation Syndrome Plus Medical Management — Ann M. Farese, Melanie V. Cohen, Barry P. Katz, Cassandra P. Smith, William Jackson III, Daniel M. Cohen, and Thomas J. MacVittie

Acute Gastrointestinal Syndrome in High-Dose Irradiated Mice — Catherine Booth, Gregory Tudor, Julie Tudor, Barry P. Katz, and Thomas J. MacVittie

Evidence of Delayed Gastrointestinal Syndrome in High-Dose Irradiated Mice — Catherine Booth, Gregory Tudor, Nicola Tonge, Terez Shea-Donohue, and Thomas J. MacVittie

The Acute Gastrointestinal Subsyndrome of the Acute Radiation Syndrome: A Rhesus Macaque Model — Thomas J. MacVittie, Ann M. Farese, Alexander Bennett, Daniel Gelfond, Terez Shea-Donohue, Gregory Tudor, Catherine Booth, Emylee McFarland, and William Jackson III

The Prolonged Gastrointestinal Syndrome in Rhesus Macaques: The Relationship between Gastrointestinal, Hematopoietic, and Delayed Multi-Organ Sequelae following Acute, Potentially Lethal, Partial-Body Irradiation — Thomas J. MacVittie, Alexander Bennett, Catherine Booth, Michael Garofalo, Gregory Tudor, Amanda Ward, Terez Shea-Donohue, Daniel Gelfond, Emylee McFarland, William Jackson III, Wei Lu, and Ann M. Farese

Development and Dosimetry of a Small Animal Lung Irradiation Platform — Ross McGurk, Caroline Hadley, Isabel L. Jackson, and Zeljko Vujaskovic

A Preclinical Rodent Model of Radiation-Induced Lung Injury for Medical Countermeasure Screening in Accordance with the FDA Animal Rule — Isabel L. Jackson, Puting Xu, Caroline Hadley, Barry P. Katz, Ross McGurk, Julian D. Down, Zeljko Vujaskovic

Biokinetics of Systemically Distributed ⁶⁰Co in the Rat: An Experimental Model Useful in Evaluating Medical Countermeasures for Internal Contamination — Waylon Weber, Melanie Doyle-Eisele, Steven K. Seilkop, and Raymond Guilmette

Software for Empirical Building of Biokinetic Models for Normal and Decorporation-Affected Data — Guthrie Miller, Luiz Bertelli, Kenneth Klare, Waylon Weber, Melanie Doyle-Eisele, and Raymond Guilmette

OTHER CONTENT

News and Notices

Health Physics Society Prospectus

Health Physics Society Affiliate Members

Author Guidelines

Advertisers Guide

Advertisers Index

Up and Coming

Health Physics (ISSN 0017-9078) is the Official Journal of the Health Physics Society and is published monthly by Lippincott Williams and Wilkins, 351 West Camden Street, Baltimore, MD 21201-2436. For news and abstracts, and to search past issues of the Health Physics Journal, please visit the Health Physics Journal website.