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Answer to Question #1498 Submitted to "Ask the Experts"Category: Doses and Dose Calculations — Internal dose calculations The following question was answered by an expert in the appropriate field: Q
How can we find out the new radiopharmaceutical dose rate in an animal study?
A
I think what you are asking is how we can determine human radiation dose estimates for new pharmaceuticals based on biokinetic data gathered in animal studies. If so, the basic procedure is to choose an animal species (a number of considerations may come in here, including suitability of the species in studying the drug of interest, cost, care issues, and others), then administer the activity, monitor the results, extrapolate the results to humans, perform a kinetic analysis, and finally calculate human radiation dose estimates using standard models. Within each of these items, there are a number of technical issues that must be considered and evaluated. It would not be possible in the space here to give a complete overview of all of these potential factors and how to resolve them. If you are needing to actually perform such a study and are unfamiliar with these issues, you might want to hire a consultant to ensure that all of the technical issues are handled well and that all details are covered. If your interest is only academic, I could send you a short technical paper that gives a few more details than the sentence above, or perhaps the above is sufficient.
If you want more information please contact our Web site editor. Please refer to this question.
Michael G. Stabin, PhD, CHP
Answer posted on 14 January 2002. The information and material posted on this Web site is intended as general reference information only. Specific facts and circumstances may alter the concepts and applications of materials and information described herein. The information provided is not a substitute for professional advice and should not be relied upon in the absence of such professional advice specific to whatever facts and circumstances are presented in any given situation. Answers are correct at the time they are posted on the Web site. Be advised that over time, some requirements could change, new data could be made available, or Internet links could change. For answers that have been posted for several months or longer, please check the current status of the posted information prior to using the responses for specific applications.
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