Real Time 3H Monitoring of Effluent Air from a Radiosynthesis Laboratory

Authors

M. L. Maiello, P. Linsalata

Abstract

Tritium, in gaseous form (T-2), is used in radiosynthesis laboratories to tag or tritiated compounds used in experimental drug research. The tritium is used as a marker for both in vivo and in vitro studies such binding assays that determine if the compound attaches to cell receptor sites of interest. During the course of tritiation, there is a potential for tritium gas release to the radiosynthesis laboratory fume hood. The amount of activity used may be as high as 74,000 MBq (2 Ci). The amount of activity released is of importance to the facility Radiation Safety Officer for air quality compliance as well as to the radiochemist for monitoring the progress of the tritiation reaction. To accomplish real-time monitoring of tritium, a measurement system was set up comprised of a commercially available ion-chamber with an audible alarm, an analog to digital signal converter and two computers equipped with measurement analysis software. This paper discusses this system.

Meeting

This abstract was presented at the 33rd Annual Midyear Meeting, "Instrumentation, Measurements, and Electronic Dosimetry", Poster Session, 1/30/2000 - 2/2/2000, held in Virginia Beach, VA.

 
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