99Mo Isotope Production Preparation at Sandia National Laboratory


M. J. McDonald, S. D. Carson, S. W. Longley, E. J. Parma, M. E. Vernon


Mo-99 is the precursor to Tc-99m and is used to produce Tc-99m generators. Tc-99m became the most widely used radioisotope in the medical industry for diagnostic applications. Sandia National Laboratories (SNL) is in the preparation phase for the production of Mo-99. Preparatory work includes reproduction and verification of the Cintichem Mo-99 production process; development of production hardware; modification of the Hot Cell Facility (HCF); reconfiguration of the Annular Core Research Reactor (ACRR) core; and preparation of documentation to meet the Good Manufacturing Practices (GMP) requirements of the U.S. Food and Drug Administration (FDA) process. In addition, radiation effects tests were performed at the Gamma Irradiation Facility (GIF) on processing chemicals and hardware used in the processing to evaluate the degradation due to the high radiation field experienced during chemical separation.


This abstract was presented at the 32nd Annual Midyear Meeting, "Creation and Future Legacy of Stockpile Stewardship Isotope Production, Applications, and Consumption", Isotope Production, Applications, and Safety Session, 1/24/1999 - 1/27/1999, held in Albuquerque, NM.

Index of Midyear Meeting Abstracts